Sunekos vs Profhilo vs Polynucleotides: Which Injectable Skin Treatment Is Right for You?

If you've been researching skin rejuvenation treatments, you've probably come across names such as Sunekos, Profhilo, Polynucleotides and Redensity 1 (Teosyal Baby Glow). Patients often ask me which one is "the best skin booster."

The truth is, there isn't one.

Although these treatments are often grouped together, they work in very different ways. Some improve hydration, others stimulate collagen production, while the newest regenerative treatments focus on supporting the skin's natural healing and repair processes.

Choosing the right treatment isn't about selecting the latest trend—it's about understanding why your skin is changing and matching the treatment to your individual concerns.

What is a skin booster?

The term skin booster has become increasingly popular, but it doesn't accurately describe every injectable treatment that improves skin quality. Some treatments are designed to deeply hydrate the skin. Others stimulate collagen and elastin production.

Some encourage tissue regeneration and reduce inflammation. Each has its place, but they are not interchangeable.

Sunekos – Best for under-eye rejuvenation and collagen stimulation

Sunekos combines hyaluronic acid with a patented blend of amino acids, providing fibroblasts with the building blocks needed to produce collagen and elastin naturally.

Rather than adding volume, it improves the quality of the skin itself.

Sunekos is particularly effective for:

• Under-eye wrinkles

• Crepey skin

• Dark circles caused by thinning skin

• Early skin laxity

• Neck lines

• Collagen banking

• Menopausal skin

Patients looking for subtle, natural improvements often choose Sunekos because it strengthens the skin without changing facial shape.

Profhilo – Best for hydration and overall skin laxity

Profhilo contains one of the highest concentrations of stabilised hyaluronic acid available in an injectable treatment.

It spreads beneath the skin, improving hydration while stimulating collagen and elastin production across larger treatment areas.

Profhilo is particularly suited to patients concerned by:

• General skin laxity

• Crepey skin

• Neck ageing

• Décolletage ageing

• Dry, dehydrated skin

• Menopausal skin

Rather than treating one specific area, Profhilo improves overall skin quality and firmness.

Polynucleotides – Best for regeneration and skin repair

Polynucleotides represent one of the newest developments in regenerative aesthetic medicine. Rather than focusing on hydration, they encourage tissue repair, support fibroblast activity and reduce chronic inflammation within the skin.

They are particularly effective for:

• Under-eye rejuvenation

• Thin skin

• Acne scarring

• Sun-damaged skin

• Menopausal skin

• Inflamed skin

• Skin with impaired healing

For patients experiencing significant skin damage or inflammatory skin ageing, polynucleotides may be the most appropriate starting point.

Redensity 1 (Teosyal Baby Glow) – Best for radiance and hydration

Redensity 1 combines hyaluronic acid with amino acids, antioxidants, vitamins and minerals. It is designed to improve hydration, skin texture and luminosity rather than significantly stimulating collagen.

It is often recommended for:

• Dull skin

• Dehydration

• Fine lines

• Smokers' skin

• Early skin ageing

• Patients wanting a healthy glow

Many patients choose Redensity 1 before holidays or special occasions because of the healthy, refreshed appearance it gives the skin.

Which treatment is best for under-eye wrinkles?

This depends entirely on the cause.

If your under-eye concerns are caused by thin, crepey skin, Sunekos or Polynucleotides are often excellent choices because they improve the quality of the skin itself. If dehydration contributes to the problem, Redensity 1 may help improve hydration and skin texture.

Not every under-eye concern requires filler, and careful assessment is essential before treatment.

Which treatment is best for neck lines?

The neck often shows signs of ageing before the face. For early neck lines and mild skin laxity, Sunekos can improve collagen production and skin quality. For more widespread dehydration and loss of firmness, Profhilo is often an excellent option. Where inflammation or significant skin damage is contributing to ageing, Polynucleotides may provide additional regenerative benefits.

Which treatment is best during menopause?

Menopause accelerates collagen loss, reduces hydration and affects skin elasticity.

Many women notice:

• Thinner skin

• Neck lines

• Crepey skin

• Loss of firmness

• Dryness

• Slower healing

Depending on your skin assessment, treatment may include:

• Sunekos to stimulate collagen production.

• Profhilo to improve hydration and firmness.

• Polynucleotides to support tissue repair and reduce inflammation.

Many patients benefit from combining treatments as part of a personalised regenerative programme.

Which treatment is best for collagen banking?

Collagen banking involves supporting collagen production before significant collagen loss occurs.

Both Sunekos and Profhilo are excellent options for patients in their thirties and forties looking to maintain healthy skin for the future.

The best choice depends on whether your priority is improving hydration, stimulating collagen or treating specific areas such as the under-eyes.

So, which is the best skin booster?

The answer depends on your skin.

Rather than asking which product is best, the better question is: What does my skin need?

Every patient's skin ages differently. Some patients need improved hydration. Others require collagen stimulation or regenerative treatments that support tissue repair.

At Dr Anatalia Aesthetics, every consultation begins with understanding why your skin is changing before recommending treatment. By selecting the most appropriate injectable—or combining treatments where appropriate—we create personalised treatment plans designed to improve skin health from within and deliver natural, long-lasting results.

Healthy skin isn't achieved by following trends. It's achieved by understanding your skin's biology and choosing treatments that support it at every stage of the ageing process.